TNF and brain infarction: It was reported in the literature that the long noncoding RNA SNHG14 promoted microglial activation by regulating miR-145–5p/PLA2G4A in cerebral infarction, and the miR-145–5p mimic reversed the increase in PLA2G4A and reduced the high levels of TNF-α and NO in BV-2 cells induced by SNHG14 overexpression (Qi et al., 2017).