HMOX1 and infarction: Lin et al. reported that upregulation of the protective heme oxygenase-1(HO-1) combined with inhibition of COX-2 and other NF-κB–dependent genes upon PPARγ activation were the primary mechanisms by which 15 days-PGJ2 and rosiglitazone prevent IR-induced neuronal necrosis and apoptosis, thereby limiting infarction area expansion.