MAPK3 and alkaline phosphatase measurement: It has also been reported that accelerating apoptosis is beneficial to the disease remission in the early stage of AP because it delays the process of cell necrosis to some extent (Cai et al., 2018b) Consistent with this, our molecular biology experiments showed that there was a significantly decreased in the expression of ERK1/2 and c-Fos when AP occurred, while QYD restored their expression to some extent.