Flex et al. (2014) had linked proinflammatory gene polymorphisms to dementia, and C-reactive protein is considered an endothelial toxin that is predictive of SVD (Mitaki et al., 2016). It is therefore no surprise that midlife systemic inflammation has been associated with the appearance of SVD in later life (Walker et al., 2017). The gene discussed is CRP; the disease is snowflake vitreoretinal degeneration.