APOE and early-onset autosomal dominant Alzheimer disease: Among its three alleles (ε2, ε3, and ε4), the individuals carrying the ε4 allele are at a higher risk of developing AD since the ApoE ε4/ε4 genotype increases fibrinogenesis in the brain of Alzheimer’s disease patients (Hultman et al., 2013; Raha-Chowdhury et al., 2018).