The aim of this study was to investigate the expression of iron proteins ferritin and hepcidin, in AD and DS serum and compare these protein levels in brain parenchyma in normal and dementiarelated diseased brain and discuss these findings in relation to the reported hyperferremia in SARS-COV-2 infected patients (Dahan et al., 2020; Gómez-Pastora et al., 2020; Hippchen et al., 2020; Zhou et al., 2020). This evidence concerns the gene HAMP and Alzheimer disease.