In contrast, hepcidin levels were substantially higher (p < 0.0001) in DS (mean ± SD: 188.32 ± 430.5 μg/L) compared to AD (36.3 ± 18.2 μg/L) and controls (25.38 ± 22.1 μg/L; Figure 1C). The gene discussed is HAMP; the disease is Alzheimer disease.