The two primary pathological hallmarks of AD are senile plaques (SP), which are extracellular deposits of Aβ derived from the β-amyloid precursor protein (APP), and neurofibrillary tangles (NFTs), primarily composed of hyper-phosphorylated tau (Goedert et al., 1995; Hardy and Selkoe, 2002). Here, APP is linked to Alzheimer disease.