There are two types of brain lesion that are the pathologic hallmarks of AD: extracellular senile plaques composed of amyloid β-peptide (Aβ), and intraneuronal neurofibrillary tangles (NFTs) consisting of paired helical filaments of hyperphosphorylated tau protein (Braak and Del Tredici, 2018). This evidence concerns the gene MAPT and Alzheimer disease.