MANF has shown protective effects in animal models of AD (Xu et al., 2019), Parkinson disease (Voutilainen et al., 2009), spinocerebellar ataxia (Yang et al., 2014), ischemic brain damage (Airavaara et al., 2010), retinal degeneration (Lu et al., 2018), cardiac ischemia (Arrieta et al., 2020), and liver injury (Sousa-Victor et al., 2019). This evidence concerns the gene MANF and Alzheimer disease.