Notably, most of the genes implicated in PD (e.g., SNCA, LRRK2, DJ-1, PINK1, and PRKN) have a critical role in synaptic function, and knockout mouse for each of the genes has demonstrated disruption of synaptic plasticity and neurotransmitter function (Plowey and Chu, 2011; Belluzzi et al., 2012; Abeliovich and Gitler, 2016). The gene discussed is SNCA; the disease is Parkinson disease.