Alzheimer’s disease is characterized by the presence of extracellular senile plaques of the amyloid-beta (Aβ) aggregated protein, intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein, and neuroinflammation (De-Paula et al., 2012; Cheng et al., 2018; Bouteiller et al., 2019; Castellani et al., 2019; Diaz-Zuniga et al., 2020). This evidence concerns the gene MAPT and Alzheimer disease.