PKR activation has also been involved in neurological conditions, including AD (Peel and Bredesen, 2003; Couturier et al., 2010; Dumurgier et al., 2013; Hugon et al., 2017) (reviewed in Hugon et al., 2017), PD (Bando et al., 2005), and HD (Peel et al., 2001; Bando et al., 2005), suggesting a role of PKR in pathologies associated to aging affecting the CNS. This evidence concerns the gene EIF2AK2 and Parkinson disease.