EIF2AK2 and Alzheimer disease: Activated PKR has been found in neuron cytoplasm, in granule-vacuolar degeneration sites, neuronal nuclei, and around senile plaques by immunohistological analysis of brains derived from AD mouse models and human AD patients postmortem biopsies (Peel et al., 2001; Chang et al., 2002; Peel and Bredesen, 2003; Hugon et al., 2017).