FADD and early-onset autosomal dominant Alzheimer disease: Levels of Fas-associated protein with death domain (FADD), an adaptor that bridges death receptor signaling to the caspase cascade indispensable for the induction of extrinsic apoptotic cell death, are significantly increased on the cortex of a mouse model of Alzheimer’s disease (5xFAD) at a presymptomatic stage when compared to WT littermates in vivo (Couturier et al., 2010).