APP and early-onset autosomal dominant Alzheimer disease: In brief, these 5XFAD mice co-overexpress human APP and presenilin 1 (PS1) carrying five familiar Alzheimer’s disease-related mutations (FAD mutations) in APP and PS1 transgenes (the Swedish mutation: K670N, M671L; the Florida mutation: I716V; the London mutation: V717I) and PS1 (M146L; L286V) driven by the Thy-1 promoter (Oakley et al., 2006).