These findings are in line with the loss of the sense of smell found in SCA38 patients and in Elovl5–/– mice (Borroni et al., 2016; Hoxha et al., 2017), suggesting a crucial role of Elovl5 in olfaction, in line with the reported importance of PUFAs availability for a correct olfactory discrimination and a proper olfactory tissue integrity (Greiner et al., 2001; Le Bon et al., 2018; Khoury et al., 2020). This evidence concerns the gene ELOVL5 and Spinocerebellar ataxia type 38.