GRIN2A and alcohol dependence: Polymorphisms in this subunit have also been implicated in human subjects with alcohol dependence lending clinical relevance to the multitude of studies in rodent models that have pointed to the importance of the GluN2A subunit in alcohol dependence (Boyce-Rustay and Holmes, 2006; Schumann et al., 2008; Domart et al., 2012; Daut et al., 2015; Jury et al., 2018; Zamudio et al., 2020).