Additionally, individuals carrying an ApoE4 allele without dementia were found to exhibit a mild but definite reduction in CMRglc comparable to the typical AD pattern when compared to non-carriers (Small et al., 1995; Reiman et al., 1996, 2001, 2004; Perry et al., 2002; Mosconi et al., 2008a). The gene discussed is APOE; the disease is Alzheimer disease.