PRKG1 and Parkinson disease: Multiple studies have reported that patients suffering from these disorders exhibited PD-like symptoms, pointing to the role of PGK deficiency in the development of idiopathic PD (Sotiriou et al., 2010; Sakaue et al., 2017; Cai et al., 2019; Le Bras, 2019; Shimizu et al., 2020).