In a mouse model of depression, Autry et al. (2011) found that ketamine and other NMDA antagonists inducing a fast antidepressant-like behavioral effect, inhibited the eukaryotic elongation factor2 (eEF2) kinase, resulting in reduced eEF2 phosphorylation and increased BDNF translation. The gene discussed is BDNF; the disease is major depressive disorder.