NR3C1 and major depressive disorder: One wonders how the activation of the HPA system and changes in cortisol levels and glucocorticoid receptors in many brain areas are related to the manifestation of depression (Pariante and Miller, 2001; Farrell and O’Keane, 2016; McEwen and Akil, 2020; Rothe et al., 2020) and what the role of mineralcorticoids might be (de Kloet et al., 2016).