CD4 and amyotrophic lateral sclerosis: The enrichment scores of most immune cell types were higher in the ALS group than in the control group; 11 immune cell types including macrophages, Tregs, Th1, Th2, Th17, activated CD4 + and CD8 + T cells, monocytes, activated dendritic cells, mast cells, and myeloid-derived suppressor cells showed significant differences in abundance between the two groups (adjusted p < 0.05, Wilcoxon test) (Figure 2B), indicating that immune cell infiltration was increased in ALS.