Genetic studies including GWAS for the most common synucleinopathies, Parkinson’s disease (PD) and dementia with LBs (DLB), have implicated SNCA gene as a highly significant genetic risk factor for these diseases (Pals et al., 2004; Mueller et al., 2005; Maraganore et al., 2006; Mizuta et al., 2006; Ross et al., 2007; Winkler et al., 2007; Myhre et al., 2008; Pankratz et al., 2009; Satake et al., 2009; Simon-Sanchez et al., 2009; Bras et al., 2014; Nalls et al., 2014). This evidence concerns the gene SNCA and synucleinopathy.