It has been reported that fucoidan extract protects against non-alcoholic fatty-liver damage (NAFLD) because of the activation of the AMPK/SIRT1/PGC1α (peroxisome proliferator-activated receptor-γ coactivator-1α) pathway in mice, which prevents lipotoxicity-related oxidative stress and inflammation (13). Here, SIRT1 is linked to metabolic dysfunction-associated steatotic liver disease.