Among significantly upregulated biological processes in lower ARHGAP25 expression, AKT/mTOR signaling (CREIGHTON_AKT1_SIGNALING_VIA_MTOR_DN) was identified because of the important role of the PI3K/AKT/mTOR signaling pathway in PAAD development (Figure 4A). Here, AKT1 is linked to pancreatic adenocarcinoma.