In the present study, our results suggested that M2Φ-Exos convey miR-370 to reduce cell apoptosis, lung fibrosis, granulocyte secretion, inflammation in OVA-induced mice, and suppress aberrant hyperplasia and inflammation in PDGF-BB-treated ASMCs, during which the suppression of FGF1 expression and inactivation of the MAPK/STAT1 are possibly implicated. The gene discussed is FGF1; the disease is pulmonary fibrosis.