The subgroup results indicated that high expression of lncRNA KCNQ1OT1 was significantly correlated with poor OS in other types of cancer (pooled HR=1.92, 95% CI: 1.32-2.79, P<0.001) and CRC (pooled HR=2.19, 95% CI: 1.37-3.51, P=0.001) with low heterogeneity (I2=0, P>0.05). This evidence concerns the gene KCNQ1OT1 and cancer.