Bioinformatically (Fig. 2C-D), our functional annotation analysis revealed that lncRNA KCNQ1OT1 was enriched in PIP3 activating AKT signaling, while hallmark annotation analysis showed that lncRNA KCNQ1OT1 was significantly associated with tumor promoting inflammation, suggesting that lncRNA KCNQ1OT1 may inhibit T cell immune response by affecting T cell metabolism through the PIP3/AKT pathway. This evidence concerns the gene KCNQ1OT1 and neoplasm.