In particular, the protein-protein interaction network relating to chromosome segregation pathway was enriched (Figure 5G), genes (ANK2, FN1, DYNC1H1, ANK3, CENPE, CENPF, PDS5B, BUB1, DDX18, MARS, and RAB1B) were co-occurred in LRP1B mutation samples of CC and HNSCC (Figure 5H). The gene discussed is BUB1; the disease is head and neck squamous cell carcinoma.