Several co-occurrence mutation genes were identified, such as TTN, MUC4, KMT2C, SYNE1, DMD, USH2A, ADGRV1, and SYNE2 in CC, TP53, TTN, CSMD3, MUC16, STNE1, FLG, and PCLO in HNSCC (Figure 5A-D). This evidence concerns the gene FLG and head and neck squamous cell carcinoma.