In our results, the expression status of LRP1B was identified as a biomarker for normal and neoplasm samples of CC and HNSCC, with AUC 0.8007 in HNSCC and 0.9024 in CC, which suggested that LRP1B could serve as a biomarker in CC and HNSCC. Here, LRP1B is linked to head and neck squamous cell carcinoma.