In a study aimed at understanding the resistance of hepatocellular carcinoma to 5-fluorouracil (5-FU), the stability of SRSF2 mRNA, the splicing regulator of caspase 2, which contributes to tumor apoptosis in response to 5-FU, was found to be decreased by DNA methylation-regulated miR-193a-3p34. The gene discussed is SRSF2; the disease is hepatocellular carcinoma.