MUC3A and non-small cell lung carcinoma: To investigate the effects of MUC3A on NSCLC cell sensitivity to TKIs in vivo, MUC3A-deficient or wild-type H1975 cells were subcutaneously implanted into the BALB/c nude mice, followed by AZD-9291 treatment (100 μg/mouse/day for 8 days, Fig. 5A).