Our results showed that regardless of patient ethnicity (Caucasian, African-American, and Asian), histological subtypes (such as adenocarcinoma and mucinous adenocarcinoma), nodal metastasis (N0 to N2), TP53 mutation status, and individual cancer stages, CRC patients expressed significantly higher CHD4 mRNA expression than healthy individuals (Fig. 1A-E). The gene discussed is TP53; the disease is cancer.