H2AX and neoplasm: Our in vivo data showed that this combination also inhibited the tumor growth (Fig. 6D) and immunoblotting also showed that the expression of apoptotic markers, such as the cleavages of PARP and Caspase 3, as well as DNA damage markers (γ-H2AX) were increased when combining oxaliplatin and SAHA (Fig. 6E).