CHD4 and cancer: As shown in Fig. 2B, most paired samples from the same CRC patients showed that CHD4 protein expression was higher in tumor tissues than in adjacent non-tumor colon epithelial tissues (About 85% of CHD4 protein expression in tumor tissues were at least 1.5 times higher than adjacent non-tumor colon epithelial tissues), suggested that CHD4 could be a diagnostic marker in CRC cancer.