In this study, we discovered that SNHG12 could activate the β-catenin signaling pathway in GC cells by not only increasing the stability of CTNNB1 mRNA by binding with HuR but also regulating YWHAZ, which binds to β-catenin to reduce the ubiquitination-based degradation of β-catenin; these effects result in the overexpression of β-catenin, thus activating the downstream pathway and promoting metastasis and EMT, for instance, by activating TCF/LEF transcription elements. Here, CTNNB1 is linked to gastric cancer.