Consistent with previous studies, our study found that ABCC5 binds to CDK1 and stably upregulates CDK1 protein levels by inhibiting its ubiquitination-mediated degradation, which in turn activates CDK1-mediated phosphorylation of AR Ser81, promoting the proliferation and invasive capacity of prostate cancer cells and the development of resistance to enzalutamide. This evidence concerns the gene ABCC5 and Familial prostate cancer.