Therefore, ABCC5 enhances the specific phosphorylation of AR at Ser81 by CDK1 through binding to CDK1 and inhibiting its protein degradation, which in turn stabilizes the protein level of CDK1 and activates the transcriptional activity of AR on downstream target genes to promote the malignant progression of prostate cancer. The gene discussed is ABCC5; the disease is Familial prostate cancer.