Systemic response to this thromboinflammatory reaction encounters the victim to venous thromboemboli [VTE], deep vein thrombosis [DVT], pulmonary thromboemboli [PTE], acute coronary syndrome [ACS], brain stroke, sepsis-induced coagulopathy [SIC], and disseminated intravascular coagulation [DIC] with increased fibrinogen, d-Dimer, IL-6, von-Willebrand factor, and decrease in antithrombin and lymphocyte count [1–6]. Here, VWF is linked to deep vein thrombosis.