FUNDC1 and myocardial ischemia: It was initially found that CK2 activity increased in ischemic preconditioning; however, the activation appeared to be an epiphenomenon and did not reduce the infarction from myocardial ischemia.293 Later, it has been demonstrated that CK2 is associated with the pathogenesis of cardiac ischemia–reperfusion injury and the dysregulated mitochondrial homeostasis through the suppression of FUNDC1-related mitophagy.294