HTT and Huntington disease: CK2 was found upregulated in cells expressing polyQ‐HTT, and this was considered as a cellular response to counteract polyQ‐HTT toxicity; consistently, CK2 inhibition enhanced polyQ‐HTT toxicity.172 A protective role of CK2 in HD was further confirmed showing that HTT phosphorylation at two N-terminus sites, Ser13 and Ser16, affects the protein conformation and subcellular localization173 (Fig. 3c).