By using both primary and immortalized bronchial epithelial cells, we did not report a direct correlation between CK2 expression/activity and CFTR rescue and, most importantly, we failed to find any significant difference in CK2 expression, activity and signaling by comparing primary cells from CF and healthy donors, suggesting that CK2 signaling is not altered in CF disease. This evidence concerns the gene CFTR and cystic fibrosis.