Recently, Du and colleagues195 identified CK2 as a regulator of the TBK1/IFN regulatory factor 3 axis, which mediates the virus immune evasion to IFN response; consistently, they found that CK2 targeting increased IFN-α and IFN-β response, and elicited host defense mechanisms against virus infection. The gene discussed is IFNA1; the disease is viral infectious disease.