To analyze whether the origin of lymphoma cells and CAFs affects survival and the induction of drug resistance of tumor cells, we studied the association between representative FL cell lines (SU-DHL4 and SU-DHL6) and DLBCL cell lines (OCI-Ly3 and OCI-Ly10) and CAFs derived from corresponding disease types (CAF1 and CAF4), respectively. This evidence concerns the gene CD8B and diffuse large B-cell lymphoma.