TRPV4 and breast cancer: Furthermore, TRPV4 can prevent phosphorylation of the ERM actin-binding proteins (ezrin, radixin and moesin) in breast cancer cells, TRPV4 mediated decrease in ERM phosphorylation is accompanied by a switch in the mechanism of cell migration from a mesenchymal mode based on actin protrusions to amoeboid with high membrane blebbing (Lee et al., 2016).