TTR and neoplasm: As shown, truncal tumor (HR = 1.462, P = .014), tumor thickness (>4 vs ≤2 mm: HR = 1.812, P = .014), higher TNM stage (stage II vs I: HR = 6.26, P = .012; stage III vs I: HR = 11.119, P = .001), no extended resection (HR = 1.644, P < .001), positive LND (HR = 2.454, P < .001), adjuvant therapy (HR = 1.309, P = .037) and early TTR (late TTR vs no recurrence: HR = 6.579, P < .001; early TTR vs no recurrence: HR = 15.678, P < .001) were significantly associated with worse OS (Table 4).