Analysis of cell survival signaling in MM cells co-cultured with wt or BMI1-KO MΦs showed that MM cells co-cultured with wt MΦs had elevated levels of pAkt, pS6 and antiapoptotic Mcl-1, and reduced levels of the cell cycle inhibitors p21 and p27. The gene discussed is BMI1; the disease is Miyoshi myopathy.