We used several different miRNAs target predicting software and selected out SOX5 as a downstream target of miR-194-5p, cause SOX5 belongs to the same family of SOX, which mediating the cell proliferation by binding HMG domine, which is vital for tumorgenesis31, and SOX2OT had shown its regulation on the stemness phenotype of cervical cancer cells and bladder cancer by modulating SOX222,32. This evidence concerns the gene SOX2-OT and urinary bladder cancer.