As depicted in Fig. 5H glutamatergic responses were significantly higher in FMRP-KO cells with respect to FMRP-WT, suggesting that even though the number of pre- and post- synaptic markers was similar in the two genotypes, the neuronal depolarization mediated by glutamatergic receptor activation is strongly upregulated in our FXS model, probably contributing to the increased network activity. The gene discussed is FMR1; the disease is fragile X syndrome.