To assess the potential effect of LYPLAL1-AS1 on adipogenesis in vivo, MSCs transfected with specific lentivirus (Lenti-NC and Lenti-LYPLAL1-AS1) were subjected to adipogenic differentiation medium for 3 days and were then mixed with Matrigel and injected subcutaneously into nonobese diabetic/severe-combined immunodeficiency (NOD/SCID) nude mice (Fig. S3a). Here, LYPLAL1 is linked to severe combined immunodeficiency.