TSC2 and posterior cortical atrophy: In another PCa model driven by AR wild-type, VPC-14449 was able to block the recruitment of the AR on chromatin binding sites for its target genes (FASN, FKBP5 and TSC2), whilst it was only able to block recruitment for FASN and FKBP5, but not the TSC2 gene in an AR-V model [111].