When combining women across the phase 2 study and BeAT-HF (n = 63 women), the pooled improvement observed in 6MWD (85 m; p < 0.001), QoL (24 points; p < 0.001), and NYHA functional class remained significant (36%; p < 0.01), and NT-proBNP reached statistical significance (54% relative reduction; p < 0.001). Here, NPPB is linked to hydrops fetalis.