Finally, in an analysis of patients enrolled in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy), those with CRT defibrillators in whom 1-year brain natriuretic peptide levels were reduced or remained low experienced significantly lower risk for subsequent HF or death (25). The gene discussed is NPPB; the disease is hydrops fetalis.