The results showed that the methylation level of LAMA3 (cg20937934) and LAMA3 (cg13270625) in chemoresistant ovarian cancer patients was significantly higher than that in chemosensitive ovarian cancer patients (cg20937934:0.72 ± 0.16 VS 0.61 ± 0.21, P = 0.01; cg13270625:0.57 ± 0.13 VS 0.44 ± 0.18, P = 0.002). This evidence concerns the gene LAMA3 and ovarian carcinoma.