MMP9 and rheumatoid arthritis: As showed in Fig. 7, YQCP, through acting on hub targets such as EGFR, C2,MMP9, may influence the mature of B cells and inhibit B cell-related IgG production, regulate oxidative stress and modulate activity of several enzymes including peroxidase and metallopeptidase to delay the occurrence and progress of RA and benefit the pre-RA or early-RA patients.