With the same cut-off value as for hepatic injury (2.5 ng/mL), the baseline plasma KL-6 level was the only significant predictor of on-treatment AE-IPF in both the univariate and the multi-variable Cox proportional-hazards regression (aHR 4.52; 95% CI 1.63–12.55; p = 0.004; Fig. 3b and Additional file 1: Table S9). The gene discussed is MUC1; the disease is idiopathic pulmonary fibrosis.