GRP and COVID-19: We found that HCDR3s of lineages in individuals with COVID-19 with moderate and severe symptoms are significantly longer than in healthy individuals from this study and the GRP (Briney et al., 2019; Figures 2B and 2C; one-way ANOVA statistics for differences in mean HCDR3 length: healthy-moderate: F1,13 = 15.7, p = 1.6 × 10−3; healthy-severe: F1,6 = 37.5, p = 8.7 × 10−4; GRP-moderate: F1,20 = 34.0, p = 1.1 × 10−5; GRP-severe: F1,13 = 41.5, p = 2.2 × 10−5).