The values of kobs for intrapleural inactivation of tPA (with 2.0–8.0 mg/kg DSP) and uPA (with 2.0 mg/kg DSP) during PAI‐1‐TFT of infectious pleural injury were 0.024±0.010 and 0.014±0.008 min−1, respectively. Here, SERPINE1 is linked to injury.