PLAT and empyema: Current trends in pharmacological treatment of empyema in humans include (i) de‐escalation of sctPA dose to use in combination with deoxyribonuclease (Hart et al., 2019; Popowicz et al., 2017), (ii) evaluation of need of deoxyribonuclease and dose timing when combined with sctPA (Innabi et al., 2018; Majid et al., 2016, 2017; Mehta et al., 2016; Thommi et al., ,2012, 2014) and (iii) comparison of the efficacy of tPA and uPA (Aleman et al., 2015; Altmann et al., 2019; Beckert et al., 2019; Bedat et al., 2019; Nie et al., 2014).