In the present study, we have analyzed the function of KCs and evaluated the effects of long‐term exercise on the phagocytic capacity of these cells, their expression of surface markers, and the secretion of steroid hormones in p62‐KO mice that spontaneously develop NAFL in association with hyperphagia‐induced obesity (Harada et al., 2013; Okada et al., 2009). This evidence concerns the gene TBCE and non-alcoholic fatty liver.