Mice with a deletion of p62/Sqstm1 (p62‐KO), a regulator of selective autophagy, show hyperphagia‐induced obesity because of abnormal leptin signaling, and exhibit phenotypes similar to those of patients with NAFLD, including insulin resistance, impaired glucose tolerance, and NAFL (Harada et al., 2013; Okada et al., 2009). The gene discussed is SQSTM1; the disease is non-alcoholic fatty liver.