Long‐term running exercise by a high fat diet‐fed hyperphagic obese mice (p62‐KO mice) prevented the development of hepatic inflammation and fibrosis in non‐alcoholic steatohepatitis, via the restoration of foreign‐body phagocytic capacity and induction of phenotypic changes in the Kupffer cells. This evidence concerns the gene SQSTM1 and metabolic dysfunction-associated steatohepatitis.