In the present study, we have shown that the foreign‐body phagocytic capacity of KCs is attenuated in the hyperphagic p62‐KO mice, a mouse model of obesity and NAFL, and that long‐term exercise ameliorates this defect and improves LPS clearance by the liver. The gene discussed is SQSTM1; the disease is obesity due to melanocortin 4 receptor deficiency.