CNP and multiple system atrophy: Yu et al. measured α-syn concentrations in putative neuronal and oligodendroglial exosomes, the latter isolated by immunoprecipitation from patient plasma using the oligodendrocyte marker 2,3-cyclic nucleotide-3-phosphodiesterase (CNPase), as a potential diagnostic biomarker for separating patients diagnosed with PD (N = 34) from those diagnosed with MSA (N = 32) [70].