By measuring the influx of the organic cation 14C-guanidinium induced by either veratridine or 5-HT, the influence of local and general anesthetics on cation influx through the fast, voltage-dependent sodium channel and through the 5-HT3-R cation channel was studied in N1E-115 mouse neuroblastoma cells (Barann et al. 1993). The gene discussed is HTR3A; the disease is neuroblastoma.