MAPK3 and central nervous system cancer: In addition, a number of studies showed that AE affected ERK 1/2 pathway in glioma and fibrosarcoma cells10, 11; it was already reported that different SSTR subtypes 1, 2, 5 and are able to affect cell proliferation of C6 glioma cells in vitro through the activation of the same intracellular pathway (inhibition of ERK1/2 phosphorylation).12