Moreover, some CYP24A1 mutations, which tend to be associated with milder hypercalcaemia, are present at a high frequency in the Caucasian population (4–20% on dbSNP), indicating that IIH may go undetected if not challenged by vitamin D supplementation, resulting in increased lifetime risk of nephrocalcinosis and nephrolithiasis [54]. Here, CYP24A1 is linked to Hypercalcemia.