Surprisingly, patients with SHMT2-low CRC (SHMT2-low+chemo, n = 108; SHMT2-high+chemo, n = 140) treated with 5-FU–based adjuvant chemotherapy had worse DFS and OS than those with SHMT2-high CRC (Fig. 5D). The gene discussed is SHMT2; the disease is colorectal carcinoma.