Primary OT-I Tg CD8+ T cells transduced with mPD-1 (Supplementary Fig. 7a) were further tested for the reduction of IFNγ production after stimulation with H-2Kb-expressing tumor cell line, EL-4 cells, with or without mPD-L1 or mPD-L2 expression (Supplementary Fig. 7b). Here, CD8A is linked to neoplasm.