First, in an experiment with severe colitis in clin/strep pretreated mice, ETBF colonization resulted in the death of 5/6 wild-type (GPR35+/+) mice, while none of the GPR35−/− mice died in the same experiment after ETBF colonization (n = 6 each, P = 0.0186, log-rank test) (Fig. 6a). This evidence concerns the gene GPR35 and colitis.