Stress-induced autophagy (lack of nutrients, hypoxia, ROS, and others) regulated by MITF factors promotes proteosynthesis and lipogenesis for subsequent proteolysis and β-oxidation of fatty acids, thereby generating ATP by OXPHOS for melanoma cell survival36, and at the same time a high level of NADH inhibits this process resulting in the dominance of glycolysis as the main energy pathway of the melanoma cell64. This evidence concerns the gene MITF and melanoma.