Indeed, hematopoietic cells that lack FANC proteins are hypersensitive to acetaldehyde treatment, resulting in increased cell death; mice deficient in both FANCD2 and ALDH2 show various developmental defects including embryonic lethality and bone marrow failure owing to genotoxicity caused by aldehyde accumulation46,47. This evidence concerns the gene ALDH2 and Bone marrow hypocellularity.