In addition, ASH1L plays a crucial role in the pathogenesis of acute leukemia with chromosomal translocations of the MLL1 gene (also known as KMT2A)9, which occur in 5–10% of acute leukemia patients and lead to very poor prognosis (only ~35% 5-year survival)13–15. Here, KMT2A is linked to acute leukemia.