KMT2A and leukemia: Similarly, pharmacologic inhibition of ASH1L with AS-99, but not AS-nc, induced differentiation in MLL leukemia cells (MV4;11 and KOPN8) as assessed by markedly (up to 50%) increased expression of the CD11B differentiation marker and cell morphology changes (Fig. 5d, e and Supplementary Fig. 8a).